Claudia Sanmiguel，MD

Claudia Sanmiguel, MD

Director, Ingestive Behavior and Obesity Program, Oppenheimer Center for Neurobiology of Stress; Division of Digestive Diseases, David Geffen School of Medicine at UCLA

Claudia Sanmiguel is the Ingestive Behaviors and Obesity Program (IBOP) director at the Oppenheimer Center for Neurobiology of Stress (CNS) and she is a clinical instructor at the UCLA Digestive Diseases Division.She was born in Bogota, Colombia where she studied Medicine at the Pontificia Universidad Javeriana and specialized in Internal Medicine and Gastroenterology.Then she moved to Alberta, Canada where she did research on gastrointestinal motility and the use of artificial pacemakers and stimulators for the treatment of gastrointestinal disorders.She continued her research career at the Cleveland Clinic in Ohio and at the Cedars Sinai Medical Center in Los Angeles, where she explored the use of pacemakers and electrical stimulators for the treatment of obesity and obesity related diabetes mellitus, as well as, studied gastric electromechanical signals related to eating behavior and satiety.As part of pursuing a research career in United States, she completed her residency in Internal Medicine at Cedars-Sinai Medical Center and trained in Gastroenterology at the University of California Los Angeles.She has continued her pursue on understanding the mechanisms that regulate eating behavior in health and in obesity, and the role of the brain/gut/microbiome axis in interpreting and regulating those behaviors.She has published several papers in well known GI and bioengineering journals and presented her research results in North American and International meetings.She currently has partial NIH funding for a study on the role of brain activity and changes in eating behavior in weight loss after bariatric surgery and how some peripheral signals coming from visceral fat and gut microbiome may play a role in obesity and weight loss.She is also doing research on neuroplasticity in brain areas related to eating hehaviors in response to neuromodulation.

Sanmiguel C, Gupta A, Mayer EA.Gut Microbiome and Obesity: A Plausible Explanation for Obesity.Curr Obes Rep.2015 Jun;4(2)***

Sanmiguel CP, Gupta A, Labus LS, Coveleskie K, KaragiannidisI , AlaverdyanM, Ashe-McNalley C, Stains J, and others.Adiposity Is Associated With Alterations Within the Brain Reward System in Adult Subjects.Gastroenterology 2015, Vol.148, Issue 4, S

Gupta A, Mayer EA, Sanmiguel CP, Van Horn JD, Woodworth D, Ellingson BM, Fling C, Love A, Tillisch K, Labus JS.Patterns of Brain Structural Connectivity Differentiate Lean from Overweight Subjects.Neuroimage-Clinical, 2015; 7: 506–

Sanmiguel CP, Coveleskie K, Gupta A, Kilpatrick L, Labus J, Ashe-McNalley C, Dutson EP, Mayer EA.Association of abdominal fat with resting state low frequency brain activity in human subjects.Neurogastroenterology & Motility.2013; 25, Suppl 1:14

Sanmiguel CP, Ito Y, Hagiike M, Conklin JL, Lalezari D, Soffer EE.The effect of eating on Lower Esophageal Sphincter electrical activity.American Journal of Physiology Gastrointest Liver Physiology.2009 Apr; 296(4): ***

Sanmiguel CP, Conklin JF, Cunneen SA, Barnett P, Phillips EH, Kipnes M, Pilcher J, Soffer EE.Gastric Electrical Stimulation with the TANTALUS System in Obese Type 2 Diabetes Patients: Effect on Weight and Glycemic Control.J Diabetes Science and Technology.2009; 3:***

Sanmiguel CP，Haddad W，Aviv R，Cunneen SA，Phillips EH，Kapella W，Soffer EE。TANTALUS TM肥胖癥系統(tǒng)：影響胃排空固體和生長激素釋放肽的血漿水平。Obes Surg。2007; 17：1503-9

Aviv R，Policker S，Brody F，Bitton O，Haddad W，Kliger a，Sanmiguel CP，Soffer EE。狗的胃電和機(jī)械活動(dòng)的晝夜模式。Neurogastroenterol Motil。2008; 20：63-8

Aviv R，Sanmiguel CP，Kliger A，Policker S，Haddad W，Hagiike M，Soffer EE。使用胃電信號(hào)進(jìn)行狗的自動(dòng)進(jìn)食檢測(cè)?法。Neurogastroenterol Motil。2008,20：369-76。

Kirsten Tillisch，MD

Kirsten Tillisch, MD

Director, Mind Body Research Program, Oppenheimer Center for Neurobiology of Stress; Associate Professor, Department of Medicine, David Geffen School of Medicine at UCLA

Dr.Kirsten Tillisch completed her undergraduate work at the Otis Institute of Parsons School of Design, earning a Bachelor of Fine Arts with Honors.She obtained her medical degree from the David Geffen School of Medicine at UCLA and was elected to the medical honor society Alpha Omega Alpha.She continued on at UCLA to complete her training in internal medicine and gastroenterology, graduating in 2003.Her clinical interests are functional bowel disorders such as irritable bowel syndrome, functional dyspepsia, and cyclic vomiting syndrome.Her research interests include brain-gut interactions , the effects of nonpharmacological therapies on functional gastrointestinal disorders, and pharmacological treatment of irritable bowel syndrome.Her recent research projects include defining resting state brain dysfunction in irritable bowel syndrome patients, evaluating the role of gut microbiota modulation on emotional processing in the brain, and assessment of neurokinin-1 receptor antagonists effects on the gut and brain in irritable bowel syndrome.She is a member of the Neuroimaging Program of the Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress.

Mayer EA, Tillisch K, Gupta A.Gut/brain axis and the microbiota.J Clin Invest.2015 Mar 2;125(3):926-38.doi: 10.1172/JCI76304.Epub 2015 Feb 17.Review.PubMed PMID: 25689247; PubMed Central PMCID: PMC***

Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K.Gut microbes and the brain: paradigm shift in neuroscience.J Neurosci.2014 Nov 12;34(46):15490-6.doi: 10.1523/JNEUROSCI.3299-14.2014.Review.PubMed PMID: 25392516; PubMed Central PMCID: PMC***

Mayer EA, Padua D, Tillisch K.Altered brain-gut axis in autism: comorbidity or causative mechanisms Bioessays.2014 Oct;36(10):933-9.doi: 10.1002/bies.201400075.Epub 2014 Aug 22.Review.PubMed PMID: 2***

Tillisch K，Labus JS。神經(jīng)影像的微生物 - 腸 - 腦軸。Adv Exp Med Biol。2014; 817：405-16。doi：10.1007 / 978-1-4939-0897-4_18。評(píng)論。PubMed PMID：2499***

Tillisch K.腸道微生物群對(duì)人類中樞神經(jīng)系統(tǒng)功能的影響。腸道微生物。2014年5月 - 6月; 5（3）：404-10。doi：10.4161 / gmic.29232。電子書2014年5月16日。審查。PubMed PMID：24838095; PubMed中央PMCID：PMC415***

Tillisch K，Labus J，Kilpatrick L，Jiang Z，Stains J，Ebrat B，Guyonnet D，Legrain-Raspaud S，Trotin B，Naliboff B，Mayer EA。用益生菌消耗發(fā)酵乳產(chǎn)品調(diào)節(jié)大腦活動(dòng)。消化內(nèi)科。2013年6月; 144（7）：1394-401,1401.e1-4。doi：10.1053 / j.gastro.2013.02.043。Epub 2013 Mar 6。PubMed PMID：23474283; PubMed中央PMCID：PMC3839572。

Elizabeth Videlock, MD

研究領(lǐng)域肥胖與代表謝

全球范圍內(nèi)肥胖流行率的快速增長與對(duì)這種流行病相關(guān)機(jī)制的重新理解一致。在許多因素中，可能的因果關(guān)系中，我們的飲食變化（加工食品消費(fèi)增加）被認(rèn)為是最重要的因素之一。由于腸是人體中最密集的殖民地和最多樣的微生物群落，并且由于腸道微生物組成和代表謝功能與飲食組成有內(nèi)在聯(lián)系，所以人們不得不質(zhì)疑腸道微生物群與肥胖之間的關(guān)系。雖然一些研究松散地關(guān)聯(lián)了肥胖與腸道微生物組成的變化，但這一領(lǐng)域的發(fā)現(xiàn)是相互矛盾的。然而，一些重要的研究已經(jīng)證明，在特定的情況下，從肥胖的供體向微生物小鼠引入微生物群能夠“傳遞”肥胖的型。這些研究對(duì)于理解腸道微生物本身能夠與宿主相互作用以改變宿主的身體組成是決定性的。大多數(shù)研究已經(jīng)在無菌小鼠中進(jìn)行。然而，一些流行病學(xué)研究已經(jīng)顯示了早期使用抗生素和在生命的頭幾年發(fā)展肥胖的傾向之間的關(guān)系。此外，在食品中添加抗生素以促進(jìn)牲畜生長的老式普遍做法支持微生物對(duì)身體組成的影響。

代表謝組學(xué)研究的進(jìn)展為理解微生物與宿主之間的關(guān)系打開了一扇新的大門。由消化道細(xì)菌產(chǎn)生的代表謝物可以進(jìn)入我們的血液，事實(shí)上，高達(dá)三分之一的人類血液中的小分子來自腸道細(xì)菌。這些代表謝物中的一些已經(jīng)與人宿主中的有益作用相關(guān)聯(lián); 而且這些代表謝物的改變也會(huì)導(dǎo)致有害的結(jié)果，例如增加炎癥和促進(jìn)胰島素抵抗和肥胖。

攝食行為與肥胖計(jì)劃（IBOP），奧本海默應(yīng)激神經(jīng)生物學(xué)中心（CNS

UCLA CNS攝食行為與肥胖計(jì)劃研究外圍信號(hào)（腸道微生物代表謝物，腸道肽，迷走神經(jīng)和脂肪組織信號(hào)傳導(dǎo)）與大腦在控制健康和肥胖的體重和飲食行為之間雙向交流的機(jī)制。近年來，大量證據(jù)明腸道微生物群與宿主體重之間存在重要聯(lián)系。無菌動(dòng)物研究明，腸道微生物組的變化可以改變飲食行為。這些行為效應(yīng)的機(jī)制尚不清楚，但可能涉及腸道微生物群的信號(hào)通過迷走神經(jīng)，腸道激素或微生物代表謝物傳遞給大腦。我們正在進(jìn)行的研究旨在確定這些相互作用的基礎(chǔ)。特別，我們旨在描述腸道微生物代表謝物譜如何通過改變與飽食，饑餓和進(jìn)食行為相關(guān)的大腦結(jié)構(gòu)/功能來控制體重。我們還將描述性別和種族/種族對(duì)肥胖的腸微生物 - 腦相互作用的影響。

研究領(lǐng)域口腔生物學(xué)

分子生物學(xué)技術(shù)的最新進(jìn)展擴(kuò)大了我們對(duì)細(xì)菌多樣性和口腔內(nèi)物種之間發(fā)生的協(xié)會(huì)群落相互作用的理解。它們導(dǎo)致我們對(duì)口腔微生物組及其在健康和疾病方面的理解的巨大進(jìn)展，不僅與口腔傳染病如蛀牙和牙齦疾病有關(guān)，而且還與全身性疾病有關(guān)。

使用獨(dú)立于文化的方法進(jìn)行的研究揭示了居住在口腔內(nèi)的多種微生物的嚴(yán)重程度。估計(jì)人口含有700多種不同的細(xì)菌種類，其中包括最復(fù)雜的微生物菌群之一。居住在口腔中的微生物的多樣性包括細(xì)菌，古細(xì)菌，螺旋體，原生動(dòng)物，支原體，酵母和真菌。微生物菌群的多樣性反映了遺傳信息的巨大多樣性和巨大的生物生理潛力。如果我們認(rèn)為平均細(xì)菌種類有2,000-6,000個(gè)基因，that 大約700個(gè)個(gè)體的口腔細(xì)菌群代表超過100萬個(gè)基因的池，比人類宿主基因多10倍。

Drs博士的主要研究興趣。加州大學(xué)洛杉磯分校牙科學(xué)院的何文淵教授和薛雪鶴博士主要關(guān)注口腔微生物在宿主健康和疾病中的作用，并探討實(shí)際的因果關(guān)系。同時(shí)，他們也積極研究個(gè)別物種的口腔微生物生態(tài)學(xué)，物種間以及多物種水平。他們的最終目標(biāo)是更好地了解口腔微生物組的生態(tài)學(xué)特征，口腔細(xì)菌種類的詳細(xì)特征將成為打擊牙科，牙周以及與口腔微生物有關(guān)的更具體和更有效的預(yù)防和治療方法的門戶全身性疾病。

目前在李惠英博士的口腔微生物組項(xiàng)目該小組著重了解口腔微生物在牙周健康和疾病中的作用。Li實(shí)驗(yàn)室通過比較健康人和牙周炎患者齦下菌群宏基因組的差異，旨在確定區(qū)分牙周健康和疾病齦下微生物群的微生物群落和宏基因組特征。此外，2型糖尿病與牙周炎的患病率和進(jìn)展相關(guān)。通過比較2型糖尿病患者和非糖尿病患者的牙周微生物群，李實(shí)驗(yàn)室正在研究宿主因素（包括免疫應(yīng)答）對(duì)牙周健康和疾病的口腔微生物群的影響。

Guo，L.，JS。McLean，Y.Yang，R.Eckert，CW Kaplan，P.Kyme，O.Sheikh，B.Varnum，R.Lux，W.Shi和X.He 。2015作為人類微生物生態(tài)學(xué)的靶向調(diào)節(jié)劑的精確引導(dǎo)的抗微生物肽。Proc Natl Acad Sci USA 112（24）：***

他，X.，JS。McLean，A.Edlund，S.Yooseph，AP Hall，SY。Liu，P.Dorrestein，E.Esquenazi，R.Hunter，G.Cheng，KE。納爾遜，勒克斯和史密斯。一個(gè)人類相關(guān)的TM7的馴化揭示了一個(gè)減少的基因組和寄生生活方式。Proc Natl Acad Sci USA 112（1）：244-9。PMCID：PM***

Wu，T.，L.Cen，C.Kaplan，X.Zhou，R.Lux，W.Shi和X.Hho。介導(dǎo)白色念珠菌（Candida albican）和有核梭桿菌（Fusobacterium nucleatum）的共聚集的細(xì)胞成分。牙科研究雜志 DOI：10.1177 / 00220345***

主要教師

Xuesong He，DDS，PhD。

Xuesong He, DDS., PhD

Assistant Adjunct Professor, UCLA School of Dentistry

UCLA School of Dentistry

20-118 CHS

Los Angeles CA 9***

Phone: (310)***

E-mail: xhe**[ta]**tistry.ucla.edu

Dr.Xuesong He is an Adjunct Assistant Professor in School of Dentistry at UCLA.Dr.He received his D.D.S.from Peking University Health Science Center in 1999, and his PhD in Microbiology from Indiana University in USA in 2006.Dr.He’s research interest includes: 1) Interspecies interaction between oral microbes; 2) culturing and studying”yet-to-be” cultivated oral microbes; and 3) studying the oral microbial ecology and its impact on human oral health and diseases.He is currently the co-principle investigator of a NIH RO1 grant on studying the unique epibiotic parasitic relationship between two oral commensal bacteria that could be involved in oral mucosal infectious disease.The international impact of his research can be proved by his over 30 well-cited publications in peer-reviewed leading scientific journals including: PNAS, ISME Journal, Advance in Dental Research, Microbiology and Molecular Biology Reviews, Journal of dental research, Journal of Endodontics, Molecular Microbiology, Microbiome Journal, Scientific Reports, Frontiers in Microbiology, Molecular Oral Microbiology, Microbial Ecology, Plos One, International Journal of Oral Science, FEMS Microbiology Letter and Journal of Bacteriology, etc.

Guo, L., JS.McLean, Y.Yang, R.Eckert, C.W.Kaplan, P.Kyme, O.Sheikh, B.Varnum, R.Lux, W.Shi and X.He.2015 A precision guided antimicrobial peptide as a targeted modulator of human microbial ecology.Proc Natl Acad Sci USA 112(24): ***

He, X., JS.McLean, A.Edlund, S.Yooseph, A.P.Hall, SY.Liu, P.Dorrestein, E.Esquenazi, R.Hunter, G.Cheng, KE.Nelson, R.Lux and W.Shi.2015.Domestication of a human-associated TM7 reveals a reduced genome and parasitic lifestyle.Proc Natl Acad Sci USA 112(1):244-9.PMCID:PM***

Wu, T., L.Cen, C.Kaplan, X.Zhou, R.Lux, W.Shi and X.He.2015.Cellular components mediating co-aggregation of Candida albican and Fusobacterium nucleatum.Journal of Dental Research.DOI:10.1177/00220345***

資助機(jī)構(gòu)/撥款號(hào)碼：NIH NIDCR 1R01DE02

標(biāo)題：“TM7-最難以捉摸的口腔門的馴化和征”

李慧英博士

Huiying Li, PhD

Assistant Professor, Department of Molecular & Medical Pharmacology; Faculty, Crump Institute for Molecular Imaging, UCLA

4339 CNSI

570 Westwood Plaza, Building

洛杉磯 CA 9***

電話：（310***

電話：（310***

電子郵件：huiying**[ta]**net.ucla.edu

網(wǎng)站：Li Lab

My interest in the microbiome research began from The Sorcerer II Global Ocean Sampling Expedition led by the J Craig Venter Institute several years ago, where I applied bioinformatics to study microbial protein families in the ocean microbiome.The current research in my lab focuses on understanding the human microbiome, the collective genome of trillions of microorganisms residing in the human body, and its interactions with the host in relation to human health and diseases.Using multi-disciplinary approaches, including genomics, metagenomics, bioinformatics, high-throughput sequencing, microbiology, and biochemistry, we aim to identify the molecular mechanism of the human microbiome in health and disease pathogenesis and to develop diagnostic markers and therapeutics for microorganism-related human diseases.By combining computational and experimental approaches, the ultimate goal of my research is to understand the human-microbiota symbiotic system at both molecular level and systems level.

My research group is highly experienced in high-throughput sequencing and data analysis with expertise in bioinformatics, 16S rDNA sequence analysis, metagenomic shotgun sequence analysis, RNA-Seq data analysis, and genome assembly, annotation and comparison.I was funded by the Human Microbiome Project (HMP) among the 15 Demonstration Projects to study the role of the human skin microbiome in acne.I am currently funded by the NIGMS and NIDCR to study the human skin microbiome and oral microbiome and their associations with diseases.

Kang D, Shi B, Erfe MC, Craft N, Li H.Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis.Science Translational Medicine.2015; 293(7): 293ra

Liu J, Yan R, Zhong Q, Ngo S, Bangayan NJ, Nguyen L, Lui T, Liu M, Erfe MC, Craft N, Tomida S, Li H.The Diversity and Host Interactions of Propionibacterium acnes Bacteriophages on Human Skin.The ISME Journal.2015; 9: 2078-2

Shi B, Chang M, Martin J, Mitreva M, Lux R, Klokkevold P, Sodergren E, Weinstock GM, Haake SK, Li H.Dynamic Changes in the Subgingival Microbiome and Their Potential for Diagnosis and Prognosis of Periodontitis.mBio.2015; 6(1): e0***

Liu J, Cheng A, Bangayan NJ, Barnard E, Curd E, Craft N, Li H.Draft Genome Sequences of Propionibacterium acnes Type Strain ATCC6919 and Antibiotic-Resistant Strain HL411PA1.Genome Announcements.2014; 2(4): e0***

Kasimatis G, Fitz-Gibbon S, Tomida S, Wong M, Li H.Analysis of Complete Genomes of Propionibacterium acnes Reveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain.BioMed Research International.2013; 2013:***

Tomida S, Nguyen L, Chiu BH, Liu J, Sodergren E, Weinstock GM, Li H.Pan-Genome and Comparative Genome Analyses of Propionibacterium acnes Reveal Its Genomic Diversity in the Healthy and Diseased Human Skin Microbiome.mBio.2013; 4(3): e0***

Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H.Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne.Journal of Investigative Dermatology.2013; 133: 2152-2

資助機(jī)構(gòu)/撥款號(hào)碼：NIH R01 GM09

標(biāo)題：“人類皮膚微生物體中痤瘡丙酸桿菌及其噬菌體的種群動(dòng)態(tài)”

資助機(jī)構(gòu)/撥款號(hào)碼：NIH R01 DE02

標(biāo)題：“健康和糖尿病患者牙周微生物群的宏基因組學(xué)研究”

Wenyuan Shi博士

研究領(lǐng)域皮膚病

皮膚是人體內(nèi)最大的器官，是抵御環(huán)境攻擊和病原體入侵的第一道防線。皮膚也是數(shù)百種微生物的宿主，包括細(xì)菌，真菌，真核細(xì)胞螨和病毒。出生后不久，不同皮膚部位的微生物群落不同，具有獨(dú)特的生理和免疫龕位。它們?cè)诟腥经h(huán)境，防止病原體定殖和感染以及引導(dǎo)宿主免疫系統(tǒng)響應(yīng)外來侵入方面發(fā)揮重要作用。駐留的微生物通過皮膚分泌物隔離營養(yǎng)物，并通過微生物群落內(nèi)的復(fù)雜相互作用和宿主與宿主皮膚形成動(dòng)態(tài)生態(tài)系統(tǒng)。組成，動(dòng)態(tài)，李實(shí)驗(yàn)室

李慧英博士的研究小組中的皮膚微生物組項(xiàng)目著重于了解皮膚微生物在健康和疾病中的分子功能。通過研究生命在人體皮膚上的微生物的基因組和轉(zhuǎn)錄組，李實(shí)驗(yàn)室研究皮膚微生物如何與宿主相互作用，并在皮膚疾病中起作用。目前正在研究兩種最常見的皮膚疾病，尋常痤瘡和特應(yīng)性皮炎中的微生物群，特別是在菌株水平和功能水平。這些研究將提供關(guān)于共生皮膚微生物群在健康和疾病中的作用的分子觀察，并且將提高我們對(duì)涉及微生物群的疾病機(jī)制的理解以及微生物群在疾病治療和皮膚健康維護(hù)中的潛在未來操縱。

電話：（310***

電子郵件：bento**[ta]**m.ucla.edu

網(wǎng)站：Laboratory

衰老研究領(lǐng)域

科學(xué)和醫(yī)學(xué)的進(jìn)步使世界各國的預(yù)期壽命穩(wěn)步提高。一些老年人現(xiàn)出對(duì)神經(jīng)變性或感染性疾病的易感性增加，以及由于衰老過程而導(dǎo)致的生理功能正常退化以外的健康逐漸下降。老年人特別有營養(yǎng)不良的風(fēng)險(xiǎn)，可導(dǎo)致功能衰退。腸道微生物群與宿主的健康和疾病密切相關(guān)，在人體新陳代表謝，免疫和神經(jīng)系統(tǒng)功能的發(fā)育和調(diào)節(jié)中起主要作用，對(duì)維持心理和生理健康至關(guān)重要。抑郁和認(rèn)知下降不一定是老化的一部分。

Helen Lavretsky博士是加州大學(xué)洛杉磯分校（UCLA）的老年精神病學(xué)家，研究興趣在于治療和預(yù)防情緒和認(rèn)知障礙。她的研究已經(jīng)明，諸如瑜伽和太極拳這樣的身心鍛煉可以幫助減少衰老成年人和緊張照顧者的抑郁和認(rèn)知能力下降。目前的研究提供參與太極和瑜伽研究，以及老年抑郁癥和輕度認(rèn)知功能障礙的藥理研究。Lavretsky博士旨在通過比較患有心境和認(rèn)知癥狀的患者中的微生物組成，以及在老年人中開發(fā)針對(duì)預(yù)防情緒障礙和認(rèn)知衰退的微生物和健康的干預(yù)措施，來研究微生物在晚期心境和認(rèn)知障礙中的作用。

Lee SM，Lavretsky H.“微生物和衰老疾病”IN：精神健康和衰老的補(bǔ)充和整合療法。編輯：Lavretsky，Sajatovic，Reynolds，牛津大學(xué)出版社正在出版。

電話：（310***

電子郵件：hlavretsky**[ta]**net.ucla.edu

Dr.Helen Lavretsky is the Geriatric Psychiatrist at UCLA with research interests in treatment and prevention of mood and cognitive disorders of aging.Her studies have already shown that mind-body exercise such as yoga and Tai Chi can help to reduce depression and cognitive decline in aging adults and in stressed caregivers.Current research studies offer participation in Tai Chi and yoga studies, as well as pharmacological studies for geriatric depression and mild cognitive impairment.

Dr.Lavretsky aims to investigate the role of microbiota in late life mood and cognitive disorders by comparing microbiome composition in those with and without mood and cognitive symptoms, and to develop interventions targeting microbiota and wellness for prevention of mood disorders and cognitive decline in older adults

David Walker博士

David Walker, PhD

Professor, Department of Integrative Biology and Physiology, UCLA

微生物核心

主席：Jonathan Jacobs博士（JJacobs**[ta]**net.ucla.edu

經(jīng)理：Venu Lagishetty博士（VLagishetty**[ta]**net.ucla.edu）

微生物核心位于健康科學(xué)大樓中心，A3-115。它對(duì)人類和動(dòng)物樣本（包括糞便，組織和腸道灌洗物質(zhì)）進(jìn)行16S核糖體RNA基因測(cè)序。

結(jié)果顯示為與Greengenes數(shù)據(jù)庫匹配的操作分類單元的計(jì)數(shù)。微生物核心還提供了額外的服務(wù)，以促進(jìn)樣品采集和多組學(xué)分析（鳥槍宏基因組學(xué)，蛋白質(zhì)組學(xué)，代表謝組學(xué)）。

可用服務(wù)：用珠子敲打的DNA提取

DNA濃度測(cè)量

對(duì)16S核糖體RNA基因（中等深度 - 即MiSeq-或高深度 - 即HiSeq）的V4區(qū)域進(jìn)行測(cè)序，霰彈槍宏基因組測(cè)序

家庭糞便采樣工具包

分裝冷凍的糞便

處理糞便和灌洗樣本的蛋白質(zhì)組學(xué)

處理糞便和灌洗樣本的代表謝組學(xué)

生物信息學(xué)核心

導(dǎo)演：珍妮弗 拉布斯博士（jlabus**[ta]**a.edu

生物信息學(xué)家：喬納森 雅各布斯博士（JJacobs**[ta]**net.ucla.edu），Swapna喬希博士（SwapnaJoshi**[ta]**net.ucla.edu）

生物信息學(xué)核心為微生物核心產(chǎn)生的16S rRNA數(shù)據(jù)分析提供了一個(gè)標(biāo)準(zhǔn)化的管道。這包括alpha多樣性，beta多樣性，主坐標(biāo)分析和差異豐度測(cè)試。生物信息學(xué)核心將安排一小時(shí)與生物信息學(xué)家協(xié)商審查結(jié)果。

定制數(shù)據(jù)分析可以與核心中的個(gè)體生物信息學(xué)家合作進(jìn)行�？梢圆捎靡韵�

方法：多變量模型中差異分類群豐度

微生物共生網(wǎng)絡(luò)

微生物模塊

分層聚類

無監(jiān)督分類

監(jiān)督分類

預(yù)測(cè)的宏基因組學(xué)多元一體化途徑分析

雙方和三方網(wǎng)絡(luò)

Procrustes疊加的數(shù)據(jù)集

日期：2018年1月26日，星期五

時(shí)間：12:00 - 1:00 PM

BSRB

演講嘉賓：Grace Hancock和Nathanael Bangayan

加州大學(xué)洛杉磯分校健康科學(xué)媒體關(guān)系名錄

Peter M.Bracke

傳播總監(jiān)

辦公室：（310）206-4

手機(jī)：（323）599-1

PBracke**[ta]**net.ucla.edu

職員名冊(cè)

艾米 艾爾賓310-267-***

aalbin**[ta]**net.ucla.edu

Brianna Aldrich310-206-***

bdeane**[ta]**tistry.ucla.edu

泰德 布勞恩310-319-***

tbraun**[ta]**net.ucla.edu

塔米 丹尼斯310-267-***

tdennis**[ta]**net.ucla.edu

菲爾漢普頓310-267-***

phampton**[ta]**net.ucla.edu

Ryan Hatoum310-267-***

rhatoum**[ta]**net.ucla.edu

Leigh跳躍者310-267-***

Lhopper**[ta]**net.ucla.edu

大衛(wèi)奧爾莫斯310-267-***

dolmos**[ta]**net.ucla.edu

恩里克里維羅310-267-***

erivero**[ta]**net.ucla.edu

Elaine Schmidt310-267-***

eschmidt**[ta]**net.ucla.edu

西米?310-319-***

ssinger**[ta]**net.ucla.edu

按字母順序跳動(dòng)

成癮醫(yī)學(xué)診所 - Leigh Hopper

管理，大衛(wèi)Geffen醫(yī)學(xué)院 - Tami丹尼斯

羅納德 里根加州大學(xué)洛杉磯分校醫(yī)療中心Tami Dennis

艾滋病Enrique Rivero

過敏和免疫學(xué)Simi Singer

老年癡呆癥護(hù)理中心即臨床Enrique Rivero

老年癡呆癥研究David Olmos

麻醉學(xué)Simi Singer

自閉癥研究和治療Leigh Hopper

減肥手術(shù) - Ryan Hatoum

生物化學(xué) - Elaine Schmidt

血液與血小板中心 - Elaine Schmidt

Blum拉美貧困與健康中心 - Enrique Rivero

大腦活動(dòng)與結(jié)構(gòu) - Leigh Hopper

乳房中心（加州大學(xué)洛杉磯分校圣莫尼卡分校

Simi Singer

業(yè)務(wù)關(guān)系和伙伴關(guān)系 - 丹尼斯